Istradefylline forty mg/day amplified peak levels and AUC of CYP3A4 substrates in scientific trials. This outcome wasn't noticed with istradefylline twenty mg/working day. Consider dose reduction of sensitive CYP3A4 substrates.rufinamide will lower the level or outcome of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Cau